Saturday, 18 August 2012

Hormones- Messengers of Fight and Flight

They are the molecular messengers at the pivot of arousal and activity. Entities posing as physiologic signalling, fulfilled by the receptors that summon and bind to them. Regulators that police the internal milieu of the body, modulating the levels and the concentrations while facilitating a response of fight or flight. Whether endocrine, paracrine or autocrine; hormones remain the biochemical masters of signalling, the molecular marvels at the core of an efficient molecular logistics en route to their target receptor. From their synthesis away from their site of interest, to their odyssey via the havens of the bloodstream to their capacity to evoke activity and arousal is only at the tip of the endocrinologic iceberg. The dexterity of modulating the flux of behavior and personality
adds further to their psychological worth, their capacity for priming the mind to a biological degree. But perhaps most revered and renowned remains their mantle as the pivots of the fight-or-flight response, a complex of secretion by glands such as the adrenal, notable for its epinephrine output. Such a response to acute stress, followed by the production of dopaminergic molecule subsequently enhancing vigor and suppressing pain, giving rise to the 'adrenaline rush'. Moreover, one may observe the dynamic processes of hormones as a direct facet of a cohesive functional unit, neuroendocrine units such as the hypothalamic-pituitary-adrenal axis or even the hypothalamus-pituitary-gonadal axis function in unison in maintaining homeostatic, enteric, immunologic and other regulatory processes. It remains conspicuous the sheer cohesion and interdependence that fulfills the molecular realm of hormones, their enthralling action and intriguing reception, further kindled by their capacity to evoke and to stimulate. And as we converge deeper than ever conceived, further than ever; from the oasis of the posterior pituitary to the extremities of a lymphatic gland we realise an internal labyrinth of not solely symphony and synchrony but action upon reaction. Down to their genesis and synthesis, hormones have an uncanny resemblance of enzymes during their initial composition and inhibition, their subsequent activation and reception. There is an added resemblance of specificity, in the case of enzymes; stereo-specificity to the substrate and target cells guided by functional receptors for their hormonal counterparts. Anything but unkempt.

No comments:

Post a Comment